Guanosine (cas 118-00-3) exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling

Add time:08/30/2019    Source:sciencedirect.com

BackgroundGuanosine (cas 118-00-3) is a natural product and an endogenous nucleoside that has shown to increase during myocardial ischemia. Platelets are critically involved in ischemic coronary events. It remains unknown, however, whether guanosine may affect platelet activation and function. We sought to investigate the potential antiplatelet and antithrombotic properties of guanosine and decipher the mechanisms behind.

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