Iridium catalyzed alkylation of 2′-hydroxyacetophenone with alcohols under thermal or microwave conditions
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Add time:08/26/2019 Source:sciencedirect.com
2′-Hydroxyacetophenone was alkylated with a range of substituted benzyl and heteroaryl alcohols to afford the corresponding C-alkylated products in good yields under microwave irradiation. The C-alkylated products were reacted with bromoacetonitrile to afford 2-amino-3-benzyl 1,4-naphthoquinone derivatives in moderate yields.
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