Furo[3,2-b]pyridine: a convenient unit for the synthesis of polyheterocycles
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Add time:08/26/2019 Source:sciencedirect.com
An efficient and rapid synthesis of furo[3,2-b]pyridine 1 is described using a one-pot Sonogashira coupling/heteroannulation sequence. Regioselective lithiation of this synthon was performed leading to various 2-substituted furo[3,2-b]pyridines. Some of them were used as substrates for short functional synthesis of polyheterocycles.
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