Original paperInhibition of non-specific leukocyte esterase activity. Absence of monocyte esterase activity due to phosphoric and thiophosphoric acid (cas 13598-51-1) ester intoxication

Add time:09/02/2019    Source:sciencedirect.com

In vitro evaluation of the effect of five insecticidal phosphoric and 11 thiophosphoric acid (cas 13598-51-1) esters on different, non-specific human leukocytes esterases indicated that most of the organic phosphor compounds studied inhibited the activity of neutral α-naphthylacetate esterase, α-naphthylbutyryl esterase, and naphthol AS acetate esterase, i.e. the monocyte esterases. The extent of inhibition was dose dependent; the inhibiting dose being identical for the various non-specific esterases. Reactivation with Obidoxim was not successful. Monocyte esterase activity in a human survivor of E 605 intoxication was detectable only after serum acetylcholinesterase had returned to normal levels. The organic phosphor compound studied, however, inhibited neither acid α-naphthylacetate esterase nor naphthol AS-D chloroacetate esterase activity.

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