Synthesis, identification and antiplatelet evaluation of 2-morpholino substituted benzoxazines

Add time:07/13/2019    Source:sciencedirect.com

A number of 2-morpholino substituted benzoxazines have been prepared in order to test their effectiveness against ADP and collagen induced platelet aggregation. The reaction of 2-thio-1,3-benzoxazines with morpholine has been generalised to enable the use of substituted benzoxazines. Two separate methods were used to prepare 7-O-2-morpholino substituted benzoxazines from 7-hydroxy-2-morpholino benzoxazines. Antiplatelet testing was carried out on 15 of the title compounds. 7-(2-Chloroethoxy)-8-methyl-2-morpholin-4-yl-4H-1,3-benzoxazin-4-one 15d and 7-[2-(4-methylpiperazin-1-yl)ethoxy]-8-methyl-2-morpholin-4-yl-4H-1,3-benzoxazin-4-one 16d showed potent activity against ADP and collagen induced platelet aggregation. The structures of the newly prepared compounds were confirmed by microanalysis as well as the analysis of IR, 1H and 13C NMR.

We also recommend Trading Suppliers and Manufacturers of Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]- (cas 85141-94-2). Pls Click Website Link as below: cas 85141-94-2 suppliers

Prev:Preparation of organophilic montmorillonite-based dimethylamino benzaldehyde-Schiff-base as antibacterial agents
Next:2-Hydroxyethoxy-closo-undecahydrododecaborate(12)([B12H11CH2CH2OH]2−) as a new prospective reagent for the preparation of closo-dodecaborate building blocks and thymidine and 2-deoxyuridine conjugates linked via short spacer)