Sub-lethal effects of dimethoate alone and in combination with cadmium on biochemical parameters in freshwater snail, Galba truncatula

Add time:08/29/2019    Source:sciencedirect.com

The objective of the present study was to evaluate the influence of the organophosphorus pesticide dimethoate and cadmium on biochemical parameters of a freshwater snail, Galba truncatula, in laboratory conditions. In 14 days, snails were exposed to 0, 100, 200, and 400 μg L−1 of dimethoate and 0.0 and 1000 μg L−1 of cadmium chloride. The results evidenced that dimethoate induces oxidative stress and alters biochemical parameters in freshwater snails. Cadmium also induced significant changes in biochemical parameters. The combination of the dimethoate and cadmium markedly increased the effects on G. truncatula. Dimethoate and cadmium mixture caused a decrease in Acetylcholinesterase (AChE), and Glucose-6-phosphate dehydrogenase (G6PDH) activities, glycogen, and total antioxidant capacity (TAN) levels, and increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutathione peroxidase (GPx), and catalase (CAT) activities, and malondialdehyde (MDA) level in exposed snails. The increased toxicity and bioaccumulation of cadmium after the exposure to the highest concentration of dimethoate indicates a synergistic effect leading to a reduced performance of the detoxification system in the snail. Dimethoate contributed to the bioconcentration of cadmium in snails and increased its toxic effects evidenced in biomarkers of oxidative stress and cell damage.

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