ArticleA concise procedure for the preparation of enantiopure 3-alkylpiperidines
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Add time:09/02/2019 Source:sciencedirect.com
Reaction of (R)-phenylglycinol with racemic methyl 4-formylhexanoate takes place with a remarkable stereoselectivity to give two diastereomeric 6-ethyloxazolopiperidones (9:1 ratio) in 76% overall yield. After LiAlH4 reduction and catalytic hydrogenation, the major isomer was converted to (S)-3-ethylpiperidine.
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