Lack of effect of intranigral administration of a dopamine analogue, (±)-3-(3-hydroxyphenyl)-N,n-propylpiperidine [(±)-3-PPP], on nigrostriatal dopamine neurones

Add time:08/26/2019    Source:sciencedirect.com

Bilateral injection of apomorphine into the zona reticulata of substantia nigra in rats reduced locomotor activity and striatal dopamine (DA) turnover. In contrast, bilateral injection of (±)-3-(3-hydroxyphenyl)-N,n-propylpiperidine [(±)-3-PPP] into the zona reticulata (ZR) did not reduce locomotor activity and did not affect striatal DA turnover. A high dose of (±)-3-PPP increased locomotor activity. Unilateral injection of (±)-3-PPP, but not of apomorphine, into the ZR induced a brief period of contraversive rotation. (±)-3-PPP may not alter nigral DA autoreceptor function but may interact with DA receptors located on non-dopaminergic nigral neurones.

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