On the mechanism of action of 4′-[(9-acridinyl)-amino] methanesulphon-m-anisidide☆

Add time:08/30/2019    Source:sciencedirect.com

When cultures of PY815 mouse mastocytoma cells were treated with the antitumour agent 4′-[(9-acridinyl)-amino]methanesulphon-m-anisidine (m-AMSA) for 15 min or 2 hr at 37°C then applied to alkaline sucrose density gradients the DNA released was smaller than the DNA of untreated cells. Under similar conditions m-AMSA failed to affect the size of DNA in swollen cells, or in isolated nuclei incubated with or without added cytoplasmic extracts. The tumour inactive m-AMSA analogue 4′[(9-acridinyl)-amino] methanesulphon-o-anisidide did not affect the size of DNA in cells treated with the drug for 15 min at 37°C while after 2 hr a small part of the DNA was cleaved to material of size intermediate between that of untreated and m-AMSA-treated cells. In toto the results suggest that additional factors are involved in the action of m-AMSA on cellular DNA.

We also recommend Trading Suppliers and Manufacturers of 2-(9-ACRIDINYL)-1-PHENYLETHANONE (cas 15539-52-3). Pls Click Website Link as below: cas 15539-52-3 suppliers

Prev:Synthesis, structure, DNA binding and photocleavage activity of a ruthenium(II) complex with 11-(9-acridinyl)dipyrido[3,2-a:2′,3′-c]phenazine ligand
Next:N-(9-acridinyl)-bromoacetamide—A powerful reagent for phase-transfer-catalyzed fluorescence labeling of carboxylic acids for liquid chromatography)