Microbial reduction of ethyl 2-oxo-4-phenylbutyrate. Searching for R-enantioselectivity. New access to the enalapril like ACE inhibitors

Add time:09/04/2019    Source:sciencedirect.com

Herein, different microorganisms were tested in the enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate in aqueous medium for the preparation of ethyl (R)-2-hydroxy-4-phenylbutyrate, a key intermediate in the production of angiotensin converting enzyme (ACE) inhibitors. The use of Pichia angusta led to the (R)-enantiomer in 81% ee.

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