Benzyl benzoate (cas 120-51-4)s: New phlorizin analogs as mushroom tyrosinase inhibitors

Add time:08/31/2019    Source:sciencedirect.com

In our research, 14 benzyl benzoates with hydroxyl(s) (3–16) were synthesized and their inhibitory activity on mushroom tyrosinase was tested. Results indicated that among these compounds, 4-hydroxybenzyl 3,5-dihydroxybenzoate (3), 4-hydroxybenzyl 2,4-dihydroxybenzoate (5), 4-hydroxybenzyl 2,4,6-dihydroxybenzoate (7), 3-hydroxybenzyl 3,5-dihydroxybenzoate (8), 3-hydroxybenzyl 2,4-dihydroxybenzoate (10) exhibited inhibitory activity with their IC50 less than 10 μM. Further studies showed these five compounds were competitive inhibitors of tyrosinase and their structure–activity relationships were investigated in this article.

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