2-Aminomethyl piperidines as novel urotensin-II receptor antagonists
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Add time:08/30/2019 Source:sciencedirect.com
A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-species active, and functional urotensin-II receptor antagonists such as 1a and 11a are described.
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