A novel and efficient synthesis of 3-aminomethyl-N-tosyl-indazoles
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Add time:09/02/2019 Source:sciencedirect.com
A practical and environmentally friendly synthesis of 3-aminomethyl-N-tosyl-indazoles is developed. The in situ formed vinyl azines are reacted with amines to furnish amino functionalized anti-hydrazones in excellent yields. Subsequent copper-catalyzed cyclization at ambient temperature is effective and desired compounds are obtained in short reaction times. Also, the formation of bisindazoles is presented for the first time.
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