Biotransformation studies on 1-chloro-2, 3-propanediol dinitrate
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Add time:07/18/2019 Source:sciencedirect.com
Metabolic studies on the coronary vasodilator, 1-chloro-2, 3-propanediol dinitrate (CPD), show that two metabolites can be isolated from the urine of dogs receiving the compound orally. The data suggest that the biotransformation of CPD commences with the splitting of the nitrate ester forming a free hydroxyl group which is then conjugated with glucuronic acid. The probable metabolites are 1-chloropropyl-3-glucuronide-2-nitrate and 1-chloropropyl-2-glucuronide-3-nitrate. Upon treatment with β-glucuronidase, these metabolites correspond to the products from the partial hydrolysis of CPD, which could only be the mono nitrate esters.
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