Original articleThe effects of aprotinin on hemostatic function during cardiac surgery

Add time:08/31/2019    Source:sciencedirect.com

The mechanism of action by which large doses of aprotinin decrease blood loss during cardiac surgery is not completely understood. In a prospective, controlled study, 30 patients undergoing cardiac surgery were given high-dose aprotinin in accordance with a commonly used regimen. Twenty untreated but otherwise comparable patients served as the control group. The effects of aprotinin therapy during cardiopulmonary bypass on coagulation parameters, the kallikreinkinin system, fibrinolysis, platelet stimulation, and the release of elastase from neutrophils were studied. The fibrinolysis parameters were the only measurements that showed clear and significant differences between the two groups. Aprotinin almost completely inhibited the formation of fibrin and fibrinogen degradation products. It is assumed that inhibition of systemic fibrinolysis and suppression of local fibrinolysis contribute to the hemostatic action of aprotinin. The study did not demonstrate a significant protective effect of aprotinin on platelets. In addition, the dose of aprotinin administered did not affect the kallikrein-kinin system or elastase. Therefore, these data suggest that the previously demonstrated hemostatic effects of aprotinin derive primarily from its antifibrinolytic action.

We also recommend Trading Suppliers and Manufacturers of aprotinin, Arg(15)-Glu(52)- (cas 114264-91-4). Pls Click Website Link as below: cas 114264-91-4 suppliers

Prev:General paperBiotinylated aprotinin: a versatile probe for the detection of serine proteinases on western blots
Next:Studies on curare-like action of the tripeptide carbobenzoxy-Gly-Gly-Arg-β-naphthylamide in mouse diaphragm)