Oral geranylgeranylacetone treatment increases heat shock protein expression in human atrial tissue
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Add time:09/01/2019 Source:sciencedirect.com
BackgroundHeat shock proteins (HSPs) are important chaperones that regulate the maintenance of healthy protein quality control in the cell. Impairment of HSPs is associated with aging-related neurodegenerative and cardiac diseases. Geranylgeranylacetone (GGA) is a compound well known to increase HSPs through activation of heat shock factor-1 (HSF1). GGA increases HSPs in various tissues, but whether GGA can increase HSP expression in human heart tissue is unknown.
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