Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents

Add time:08/29/2019    Source:sciencedirect.com

Compounds 10a–10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081–0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5–25 ppm levels in the feed.

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