Synthesis of ceramidated GLA-60 derivatives
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Add time:08/29/2019 Source:sciencedirect.com
Ceramidated GLA-60 derivatives 11 and 11′ were synthesized from 1 via glycosidation of ceramide derivative 12 as a glycosyl acceptor with GLA-60 derivative 5 as a glycosyl donor, and successive conversion. Compound 11′ showed only weak LPS-antagonistic activity without showing any LPS-agonistic activity.
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