Research papersStructure and tumor necrosis factor-inducing activity of dispersed particles of a lipid A analogue, GLA-60, and phosphatidylcholine mixture

Add time:09/04/2019    Source:sciencedirect.com

A synthetic monosaccharide-analogue of lipid A, GLA-60, was co-dispersed with egg PC in aqueous solution. The size distribution and structure of the dispersed particles were investigated by the dynamic light scattering (DLS) and transmission electron microscopic (TEM) methods. The particles were of liposomal structure with homogeneous size. The leakage of CF out of the liposomes in rat plasma was suppressed by augmenting GLA-60. Fluorescence anisotropy measurements showed that GLA-60 in lipid bilayers led to a rigid structure of the membranes. The activity of tumor necrosis factor (TNF) induction in mice increased with the content of GLA-60 in sonicated liposomes. The results showed that these liposomes were useful as GLA-60 formulations.

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