Mescaline-induced changes of brain cortex ribosomes
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Add time:07/15/2019 Source:sciencedirect.com
The effect of mescaline sulfate on the binding of aminoacyl-tRNA by brain cortex ribosomes was studied. The poly U-directed binding of 14C-phenylalanyl-tRNA in vitro was moderately inhibited by mescaline. The pretreatment of normal ribosomes with mescaline caused a decrease of their phenylalanyl-tRNA binding capacity. The pretreatment of brain cortex slices with mescaline also decreased the phenylalanyl-tRNA binding capacity of the ribosomes isolated from the slices so treated. This was true in assays with phenylalanyl-tRNAs from both Escherichia coli and yeast. This inhibitory effect was dependent on the concentration and length of treatment of brain cortex slices with mesaline.
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