Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain

Add time:07/19/2019    Source:sciencedirect.com

The effects of mescaline and d-lysergic acid diethylamide (LSD) applied by microiontophoresis to single raphe neurons were compared to the effects of mescaline and LSD given systemically. LSD inhibited all raphe cells when given intravenously (i.v.) or microiontophoretically. No decrease in action potential size was seen in either case during the onset or recovery stages. Mescaline i.v., 2–8 mg/kg, produced an inhibition of a sub-population of these cells. As in the case of LSD, there was no decrease in action potential size. Microiontophoretic mescaline produced a slowing of firing rate at high ejection currents. In contrast to i.v. or microiontophoretic LSD or i.v. mescaline, the slowing produced by microiontophoretic mescaline was always associated with a decrease in action potential size. Furthermore, there was no correlation between the populations of cells depressed by microiontophoretic mescaline and i.v. mescaline. These data indicate that mescaline has differing effects on raphe neurons depending on whether it is given systemically or microiontophoretically. In contrast, LSD given systemically or microiontophoretically has similar effects on raphe neurons.

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