Thiol-activated fluorescent probe for sensitive detection and imaging of proteins

Add time:09/06/2019    Source:sciencedirect.com

A microenvironment-sensitive probe SCD is developed with a thiol-activated functional group, which could identify specific proteins containing free cysteine residues, such as human serum albumin (HSA), bovine serum albumin (BSA), and β-lactoglobulin. The probe displays good selectivity and sensitivity toward thiol-containing proteins over other proteins, ions, and amino acids under physiological conditions. Due to the twisted intramolecular charge transfer property, SCD exhibits a fluorescence “turn-on” which is utilized for the quantitative detection of trace HSA contents in urine and serum media for the assessment of kidney function and diagnosis of renal diseases. Furthermore, SCD realizes HSA imaging in human breast cancer cells.

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