Microwave promoted amination of 3-Bromoisoxazole (cas 111454-71-8)s

Add time:09/01/2019    Source:sciencedirect.com

This Letter describes the amination of 3-bromoisoxazoles by a nucleophilic aromatic substitution reaction. We have found 3-bromoisoxazoles to be inert to substitution under thermal conditions, however, the employment of phosphazene bases under microwave irradiation facilitates the amination process and allows the corresponding 3-aminoisoxazoles to be isolated in moderate yield.

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