Ring opening of 2-acylaziridines by acid chlorides

Add time:08/31/2019    Source:sciencedirect.com

Good nucleophilicity of the ring nitrogen in chiral (2R,1′R)-2-acyl-(1′-phenylethyl)aziridines initiated the reaction with various acid chlorides to form the corresponding acylaziridinium ion intermediates whose rings were opened by the chloride anion to yield the β-amino-α-chlorocarbonyl compounds. The subsequent displacement of the chloride with the internal oxygen nucleophile originated from methylchloroformate, acetyl chloride, and methyl chlorooxoacetate yielded oxazolidin-2-ones, β-amino-α-acetyloxypropionates, and morpholin-2,3-diones, respectively.

We also recommend Trading Suppliers and Manufacturers of METHYL 2-(2-((CHLOROCARBONYL)METHYL)-1,3-DIOXOLAN-2-YL)ACETATE (cas 111463-18-4). Pls Click Website Link as below: cas 111463-18-4 suppliers

Prev:Microwave promoted amination of 3-Bromoisoxazole (cas 111454-71-8)s
Next:A convenient one-pot synthesis of substituted 2-pyrone derivatives)