Short communicationAntinociception after intracerebroventricular administration of naltrindole in the mouse

Add time:09/01/2019    Source:sciencedirect.com

Intracerebroventricular (i.c.v.) injection of the δ-opioid receptor antagonist naltrindole hydrochloride (2.2–22.2 nmol) in mice produced a dose-dependent increase in tail flick and hot plate latencies with respective ED50 and 95% confidence limits of 10.6 (8.3–13.9) and 16.4 (9.2–62.3) nmol. This increase in response latencies was antagonized by 1 mg/kg s.c. naloxone or by i.c.v. coadministration of 1.4 nmol ICI-174,864, a selective peptidergic δ-receptor antagonist. Pretreatment 24 h earlier with the irreversible μ-receptor antagonist β-funaltrexamine (6 nmol i.c.v.) or 1 h earlier with the selective κ-receptor antagonist nor-binaltorphimine (100 nmol i.c.v.) did not attenuate the antinociceptive effects of naltrindole. These data indicate that high doses of naltrindole may have agonist activity at supraspinal δ-opioid receptors in the mouse.

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