Antitussive effects of naltrindole, a selective δ-opioid receptor antagonist, in mice and rats

Add time:09/06/2019    Source:sciencedirect.com

The effects of naltrindole, a selective δ-opioid receptor antagonist, on the capsaicin-induced cough reflex in mice and rats were studied. Intraperitoneal administration of naltrindole decreased the number of coughs both in mice and rats dose dependently. The cough-depressant effects reached a peak 15 min after the administration of naltrindole and lasted more than 120 min. Pretreatment with [D-Pen2, D-Pen5]enkephalin, a selective δ-opioid receptor agonist, partially but significantly reduced the antitussive effect of naltrindole. Blockade of ϰ-opioid receptors by pretreatment with nor-binaltorphimine also partially antagonized the antitussive effect of naltrindole. However, the antitussive effect of naltrindole was not antagonized by β-funaltrexamine, a selective μ-opioid receptor antagonist. Thus, it is possible that the antitussive effect of naltrindole may be mediated, in part, by ϰ-opioid receptors. The present results provide evidence for the development of δ-opioid antagonists, especially naltrindole, for use as antitussive drugs.

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