Original articleSynthesis of 6-aminomethyl derivatives of benzopyran-4-one with dual biological properties: Anti-inflammatory-analgesic and antimicrobial

Add time:09/02/2019    Source:sciencedirect.com

A series of 6-aminomethyl-2-aryl-1-benzopyran-4-one derivatives (10–24) were synthesized. The compounds were tested for anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. Among the tested compounds, six compounds 11, 13, 16, 18, 21 and 23 showed higher degree of anti-inflammatory activity (>75% activity of standard drug ibuprofen). In addition to remarkable anti-inflammatory activity, analgesic activity was found to be comparable with that of the standard drug ibuprofen. Compounds 16 and 21 showed a significant GI protection (with respect to ulcerogenesis) and a marked decrease in lipid peroxidation values whereas compounds 11 and 16 were found to possess antimicrobial activity against Staphylococcus aureus, Escherichiacoli, Rhizopus oryza and Penicillum citrum with an MIC of 10 μg/mL.

We also recommend Trading Suppliers and Manufacturers of 4(5H)-Thiazolone, 2-amino-5-(aminomethyl)- (cas 111506-20-8). Pls Click Website Link as below: cas 111506-20-8 suppliers

Prev:New (aminomethyl)phosphines via selective hydrophosphination and/or phosphorus based Mannich condensation reactions
Next:Synthesis and α-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-β-d-glucopyranosides)