Solubility of ionization behavior of the antifungal α-( 2,4-Difluorophenyl) -α-[(1-(2-(2-pyridyl)phenylethenyl)]-1H-1, 2,4-triazole-1-ethanol bismesylate (XD405)
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Add time:07/17/2019 Source:sciencedirect.com
α-(2,4-Difluorophenyl)-α-[(1-(2-(2-pyridyl)phenylethenyI)]-1H-1,2,4-triazole-1-ethanol bismesylate (XD405) exhibits exceptional solubility for a triazole antifungal. The solubility of XD405 in water is high (790 mg/ml at pH 1.51). Changes in pH have a dramatic effect on the solubility with values of 3 μg/ml at pH 6. The high solubility is due to self-association. Surface tension studies show a critical micelle concentration of 10.9 mg/ml.
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