Comparative mutagenesis of quinolines☆

Add time:09/05/2019    Source:sciencedirect.com

Quinoline, 8-hydroxyquinoline, 8-nitroquinoline, and 8-aminoquinoline are mutagenic in Salmonella when assayed by histidine reversion. Metabolic activation is required for the maximal effect. Frameshift mutagenesis appears to be the mechanism with 8-nitro- and 8-aminoquinoline. Quinoline and 8-hydroxyquinoline affect only the sensitive TA100 (missense, R factor) strain. 8-Amino-and 8-hydroxyquinolines induce chromatid aberrations in human leukocytes. 8-Nitroquinoline has no effect at the concentrations tested. 8-Aminoquinoline is not effective in yeast when assayed by forward mutation, gene conversion, or mitotic recombination; fluctuation tests show a weak effect. 8-aminoquinoline is not an effective mutagen in Drosophila when assayed for sex-linked recessive lethals by an adult feeding method.

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