Chronic administration of 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE (cas 19716-56-4), an endogenous amine in the brain, induces parkinsonism in a primate☆

Add time:09/07/2019    Source:sciencedirect.com

1-Benzyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (1BnTIQ·HCl) (22 mg/kg per day) was subcutaneously injected into a monkey, Macaca fascicularis for 66 days to investigate its acute and chronic effects. Parkinsonism-like motor symptoms appeared, and the acute toxicity was stronger than the chronic toxicity. This result suggested that 1BnTIQ may induce parkinsonism in humans. 1BnTIQ content in various regions of the monkey brain was determined by the gas chromatography-selected ion-monitoring method, but no significant variation was found.

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