Original articleSynthesis, structure and DNA cleavage studies of coumarin analogues of tetrahydroisoquinoline and protoberberine (cas 19716-69-9) alkaloids

Add time:09/07/2019    Source:sciencedirect.com

Novel molecular matrices have been derived from coumarin-4-acetic acids and β-phenylethylamines using the Bischler–Napieralski protocol which has led to the synthesis of analogues of tetrahydropapaverine in which the dimethoxybenzene moiety has been replaced by substituted coumarins. One carbon homologation has led to cyclization at the C3 position of coumarin generating the protoberberine (cas 19716-69-9) skeleton. Structures have been confirmed by diffraction studies. The results showed that compounds 6e, 6f, 7e and 7f were found to be very effective against DNA samples of Gram positive bacterium Staphylococcus aureus and fungus Aspergillus niger.

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