Integrated pharmacokinetics of five protoberberine (cas 19716-69-9)-type alkaloids in normal and insomnic rats after single and multiple oral administration of Jiao-Tai-Wan

Add time:09/09/2019    Source:sciencedirect.com

Ethnopharmacological relevanceJiao-Tai-Wan (JTW), an important herbal formula consists of Rhizoma coptidis and Cortex cinnamomi powder, is a famous prescription which has been used for centuries to treat insomnia in Traditional Chinese Medicine. The purpose of this study is to compare the pharmacokinetic properties of five protoberberine-type alkaloids (i.e. berberine, palmatine, coptisine, epiberberine and jatrorrhizine), the main bioactive constituents in JTW, between normal and insomnic rats. We also investigate the differences between single-dose and multiple-dose pharmacokinetics of five protoberberine-type alkaloids.

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