Macrolide biosynthesis: A single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin (cas 19721-56-3) in Streptomyces venezuelae

Add time:09/02/2019    Source:sciencedirect.com

The final step in the biosynthesis of methymycin, neomethymycin, and picromycin (cas 19721-56-3) is an hydroxylation, shown to be carried out by the cytochrome P-450 monooxygenase, PicK. Direct comparison of the relative kcatKm values for the two substrates, YC-17 and narbomycin, showed a threefold rate preference of picK for narbomycin.

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