Synthesis of 5-substituted 2-(4- or 3-methoxyphenyl)-4(1H)-quinolones

Add time:09/02/2019    Source:sciencedirect.com

5-Substituted 7-methoxy-2-(4- or 3-methoxyphenyl)-4(1H)-quinolones 8–17 have been synthesised in good yields from the corresponding 7-methoxy-2-(4- or 3-methoxyphenyl)-5-trifluoromethanesulfonate-4(1H)-quinolones 7 via palladium-mediated cross-coupling reactions or aromatic nucleophilic substitution (SNAr) reactions.

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