Synthesis and Photophysical Studies on N1-(2′-O,4′-C-Methyleneribofurano-nucleoside-3′-yl)-C4-(coumarin-7-oxymethyl)-1,2,3-triazoles

Add time:08/31/2019    Source:sciencedirect.com

A series of eight N1-(2′-O,4′-C-methylene-β-D-ribofuranonucleoside-3′-yl)-C4-(coumarin-7-oxymethyl)-1,2,3-triazoles have been synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition reaction of 3′-azido-3′-deoxy-2′-O,4′-C-methyleneuridine and 3′-azido-3′-deoxy-2′-O,4′-C-methylene-5-methyluridine with 7-propargyloxy coumarins in 82–88% yields. The synthesized coumarintriazolyl-bicyclonucleoside conjugates possess an extra bridge between 2′-O and 4′-C in the nucleoside moiety, which facilitates its pre-organization into N-type sugar puckering. This was confirmed by X-ray crystal structure studies on one of the conjugates, i.e. on N1-(3′-deoxy-2′-O,4′-C-methylene-5-methyluridin-3′-yl)-C4-(4-phenylcoumarin-7-oxymethyl)-1,2,3-triazole. Photophysical studies carried out on the synthesized compounds demonstrate that they possess useful level of fluorescence with Stokes shift of approximately 70 nm.

We also recommend Trading Suppliers and Manufacturers of 3-Benzoyl-4-phenylcoumarin (cas 19725-29-2). Pls Click Website Link as below: cas 19725-29-2 suppliers

Prev:Synthesis of 5-substituted 2-(4- or 3-methoxyphenyl)-4(1H)-quinolones
Next:Research paperSynthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole)