Resolution of (±)-mandelic- and (±)-2-(chlorophenoxy)propionic- acid derivatives by crystallization of their diastereomeric amides with (R)- or (S)-α-arylethylamines

Add time:07/15/2019    Source:sciencedirect.com

An alternative and cost effective route for the resolution in high ees (95–99%) of (±)-mandelic- and (±)-2-(chlorophenoxy)propionic- acid derivatives is reported. The key step involves the covalent derivatization and separation of their diastereomeric amides with (R)- or (S)-α-arylethylamines.

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