Influence of THIOSTREPTON (cas 1393-48-2) binding on the ribosomal GTPase associated region characterized by molecular dynamics simulation
-
Add time:09/09/2019 Source:sciencedirect.com
The THIOSTREPTON (cas 1393-48-2) antibiotic inhibits bacterial protein synthesis by binding to a cleft formed by the ribosomal protein L11 and 23S’s rRNA helices 43–44 on the 70S ribosome. It was proposed from crystal structures that the ligand restricts L11’s N-terminal movement and thus prevents proper translation factor binding. An exact understanding of thiostrepton’s impact on the binding site’s dynamics at atomistic resolution is still missing. Here we report an all-atom molecular dynamics simulations of the binary L11·rRNA and the ternary L11·rRNA·thiostrepton complex (rRNA = helices 43–44). We demonstrate that thiostrepton directly impacts the binding site’s atomic and biomacromolecular dynamics.
We also recommend Trading Suppliers and Manufacturers of THIOSTREPTON (cas 1393-48-2). Pls Click Website Link as below: cas 1393-48-2 suppliers
Prev:THIOSTREPTON (cas 1393-48-2) binds to malarial plastid rRNA
Next:Anion recognition by THIOSTREPTON (cas 1393-48-2)) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Anion recognition by THIOSTREPTON (cas 1393-48-2)09/10/2019
- THIOSTREPTON (cas 1393-48-2) binds to malarial plastid rRNA09/08/2019
- Functional roles in S-adenosyl-l-methionine binding and catalysis for active site residues of the THIOSTREPTON (cas 1393-48-2) resistance methyltransferase09/07/2019
- Synthesis of dehydroalanine fragments as THIOSTREPTON (cas 1393-48-2) side chain mimetics09/06/2019
- Synthetic studies on THIOSTREPTON (cas 1393-48-2) family of peptide antibiotics: synthesis of the dihydroquinoline portion of THIOSTREPTON (cas 1393-48-2), the siomycins, and the thiopeptins09/05/2019
- THIOSTREPTON (cas 1393-48-2) is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes09/04/2019
- Discovery and efficient synthesis of a biologically active alkaloid inspired by THIOSTREPTON (cas 1393-48-2) biosynthesis09/03/2019
- Development of co-solvent freeze-drying method for the encapsulation of water-insoluble THIOSTREPTON (cas 1393-48-2) in sterically stabilized micelles09/02/2019
- Short communicationTranscript-level responses of Plasmodium falciparum to THIOSTREPTON (cas 1393-48-2)09/01/2019