Short communicationAlkali cation transport through liposomes by the antimicrobial Fusafungine (cas 1393-87-9) and its constitutive enniatins

Add time:09/02/2019    Source:sciencedirect.com

Fusafungine (cas 1393-87-9) is a peptide antibiotic mixture composed of several enniatins and active against Grampositive bacteria. Ionophoric properties of fusafungine have been studied in liposomes by measuring protoncation exchange by both fluorescence and 31P-nuclear magnetic resonance (NMR) and have been compared to those of its constituent enniatin peptides. Fusafungine, as well as enniatins, transport cations through a mobile carrier mechanism selective for K+vs. Na+ and involving two antibiotic molecules. The transport efficiencies of the various enniatins appear to be related to their hydrophobicity, in agreement with a previously proposed “sandwich” transport model. The ionophoric properties of crude fusafungine may be involved in its antibiotic action and its local therapeutic properties.

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