CommunicationEffect of Fusafungine (cas 1393-87-9) on adherence of Haemophilus influenzae type b to human epithelial cells in vitro

Add time:09/03/2019    Source:sciencedirect.com

Haemophilus influenzae, a normal host of the nasopharynx of humans, may become a pathogen. The first step of infection is adherence to epithelial cells of the nasopharynx through glycopeptidic adhesins, or pili. Adherence to human epithelial cells in continuous lines, HeLa and Hep2, of 8 piliated strains of Haemophilus influenzae isolated from human infections of the respiratory tract was studied in vitro in ihe presence of Fusafungine (cas 1393-87-9), a local bacteriostatic antibiotic. When the bacteria were grown in the presence of 0.5 × the MIC, fusafungine afforded 45–75% of adherence inhibition, but this inhibitory effect did not parallel the MICs. In contrast, no significant effect could be observed either when epithelial cells were exposed to 0.5 × the MIC before use in the adherence assay, or when this assay was performed in the presence of 0.5 × the MIC of fusafungine. The partial adherence inhibition observed suggests that fusafungine interacts with the bacterial binding sites but that other mechanisms may contribute to the inhibitory process. This effect of fusafungine should prevent but not eradicate colonization of the nasopharyngeal mucosa by Haemophilus influenzae and may account for the therapeutic efficacy reported in infections of the respiratory tract due to Haemophilus influenzae.

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