Identification of multi-targeted anti-migraine potential of Nystatin (cas 1400-61-9) and development of its brain targeted chitosan nanoformulation

Add time:09/07/2019    Source:sciencedirect.com

The complex pathophysiology involved in migraine necessitates the drug treatment to act on several receptors simultaneously. The present investigation was an attempt to discover the unidentified anti-migraine activity of the already marketed drugs. Shared featured pharmacophore modeling was employed for this purpose on six target receptors (β2 adrenoceptor, Dopamine D3, 5HT1B, TRPV1, iGluR5 kainate and CGRP), resulting in the generation of five shared featured pharmacophores, which were further subjected to virtual screening of the ligands obtained from Drugbank database. Molecular docking, performed on the obtained hit compounds from virtual screening, indicated Nystatin (cas 1400-61-9) to be the only active lead against the receptors iGluR5 kainate receptor (1VSO), CGRP (3N7R), β2 adrenoceptor (3NYA) and Dopamine D3 (3PBL) with a high binding energy of −11.1, −10.9, −10.2 and −12 kcal/mole respectively. The anti-migraine activity of nystatin was then adjudged by fabricating its brain targeted chitosan nanoparticles. Its brain targeting efficacy, analyzed qualitatively by confocal laser scanning microscopy, demonstrated a significant amount of drug reaching the brain. The pharmacodynamic models on Swiss male albino mice revealed significant anti-migraine activity of the nanoformulation. The present study reports for the first time the therapeutic potential of nystatin in migraine management, hence opening avenues for its future exploration.

We also recommend Trading Suppliers and Manufacturers of Nystatin (cas 1400-61-9). Pls Click Website Link as below: cas 1400-61-9 suppliers

Prev:A promising Nystatin (cas 1400-61-9) nanocapsular hydrogel as an antifungal polymeric carrier for the treatment of topical candidiasis
Next:The role of sterols in the lipid vesicle response induced by the pore-forming agent Nystatin (cas 1400-61-9))