Preparation, physicochemical characterization and anti-fungal evaluation of the Nystatin (cas 1400-61-9)-loaded Eudragit RS100/PLGA nanoparticles
-
Add time:09/09/2019 Source:sciencedirect.com
Purpose of the present research work was to evaluate the effect of carrier composition and nanoparticles surface charge on the physicochemical and antifungal properties of the Nystatin nanoparticles. For preparation of the nanoparticles, a positively charged polymer, Eudragit RS100, and a negatively chargedPLGA were used in different ratios. The nanoparticles were evaluated for size, zeta potential, polydispersity index, loading efficiency, and release properties. DSC, SEM, XRPD, and FT-IR were performed to analyze the physicochemical properties of the nanoparticles. Antifungal activity of the nanoparticles was evaluated by determination of MICs against C. albicans. All nanoparticles were spherical with mean size, polydispersity index, zeta potential and loading efficiency in the range of 128 ± 6.5–362.9 ± 2.6 nm, 0.196 ± 7.1–0.279 ± 4.3, –0.885–(+5.65) mV and 18.75 ± 2.4, 47.58 ± 2.1%, respectively. The results from XRPD and DSC studies showed reduced crystallinity in the formulations. The FT-IR spectra revealed that there was no chemical interaction between the drug and polymers. The results demonstrated that the antifungal properties of the nanoparticles were increased with decreasing PLGA concentration. In conclusion, the prepared Nystatin nanoparticles with appropriate physicochemical properties and improved potency against C. albicans were formulated. This improvement could be attributed to the modified surface characteristics as well as increased fungal drug adsorption.
We also recommend Trading Suppliers and Manufacturers of Nystatin (cas 1400-61-9). Pls Click Website Link as below: cas 1400-61-9 suppliers
Prev:The role of sterols in the lipid vesicle response induced by the pore-forming agent Nystatin (cas 1400-61-9)
Next:Effect of hydrogen bonding interaction on the photophysics of α-amino-ORCEIN (cas 1400-62-0)) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- The role of sterols in the lipid vesicle response induced by the pore-forming agent Nystatin (cas 1400-61-9)09/08/2019
- Identification of multi-targeted anti-migraine potential of Nystatin (cas 1400-61-9) and development of its brain targeted chitosan nanoformulation09/07/2019
- A promising Nystatin (cas 1400-61-9) nanocapsular hydrogel as an antifungal polymeric carrier for the treatment of topical candidiasis09/06/2019
- Original Research ArticleEvaluation of mucoadhesive oral films containing Nystatin (cas 1400-61-9)09/05/2019
- Development of a gum base formulation for Nystatin (cas 1400-61-9); a new drug delivery approach for treatment of oral candidiasis09/04/2019
- Stability and efficacy of combined Nystatin (cas 1400-61-9) and chlorhexidine against suspensions and biofilms of Candida albicans09/03/2019
- Case ReportA Drug–drug Interaction Between Cyclosporine and Nystatin (cas 1400-61-9)09/02/2019
- Comparison of the efficacy of indocyanine green-mediated photodynamic therapy and Nystatin (cas 1400-61-9) therapy in treatment of denture stomatitis09/01/2019