‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold

Add time:07/15/2019    Source:sciencedirect.com

Sodium acetate catalyzed assembling of salicylaldehydes, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one in small amount of ethanol gives rapidly (5 min) substituted 4-pyridinyl-2-amino-4H-chromenes in 82–99% yields. This novel domino reaction opens the fast, facile, and flexible way to the new type of functionalized 2-amino-4H-chromene scaffold containing uracil-like moiety, which are relevant compounds for diverse biomedical applications.

We also recommend Trading Suppliers and Manufacturers of 1-(4-PYRIDINYL)-4-PIPERIDINECARBOXYLIC (cas 210962-09-7). Pls Click Website Link as below: cas 210962-09-7 suppliers

Prev:Toxic effects of 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal on the maturation and subsequent development of murine oocyte
Next:Effects of the affinity ligands 14-β-chloroacetylnaltrexone and 14-β-bromoacetamidomorphine on [3H]-dihydromorphine binding sites in rat brain)