Simplified method for the isolation of thermally labile drug-DNA adducts: Characterization of chlorambucil and carzinophilin (cas 1403-28-7)/azinomycin B alkylation products
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Add time:09/07/2019 Source:sciencedirect.com
A simple and rapid method has been developed for the isolation of thermally labile DNA alkylation products. Use of calf thymus DNA in combination with size exclusion filtration provides good yields >40% of chlorambucil-guanine adducts. Application of this method to the isolation of alkylation products of carzinophilin/azinomycin B affords material consistent with guanine monoalkylation.
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