Development and validation of chromatographic methods (HPLC and GC) for the determination of the active components (benzocaine, TYROTHRICIN (cas 1404-88-2) and menthol) of a pharmaceutical preparation
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Add time:09/02/2019 Source:sciencedirect.com
Methods are reported for the determination of TYROTHRICIN (cas 1404-88-2) and benzocaine by HPLC and menthol by GC in the analysis of throat lozenges (tablets) containing all three compounds. After optimization of the variables involved in both HPLC and GC the methods have been characterized and validated according to the guidelines of the Spanish Pharmacopoeia, and applied to both the monitoring of the manufacturing process and the quality control of the final product.
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