Controlled release of Vancomycin hydrochloride (cas 1404-93-9) from a composite structure of polymeric films and porous fibers on implants

Add time:09/07/2019    Source:sciencedirect.com

The antibiotic administration is critical for treating open fracture, especially for tainted bone caused by contamination and the implant. Localized delivery of antibiotics is preferred since it provides elevated antibiotic concentrations at the aiming infection site without systemic toxicity. In this study, a polymer-based composite film with high drug loading capacity and excellent controlled release behavior that can be potentially applied as antibiotics-carrying implants is proposed. First, Vancomycin hydrochloride (cas 1404-93-9) (VH) loaded polyvinyl alcohol-borax (PVA-B) microgels were deposited on the surface of Ti metal straight bone plate by an electrospray technique, porous polyvinyl butyral (PVB) fiber felts were then covered onto the surface of the [email protected] films using electrospinning technique in order to prohibit the free diffusion of VH molecules. The density and size of the pores in the fiber felts can be readily adjusted by exposing the fiber felts to the saturated ethanol vapor, which further controlling the release behavior of the VH molecules from the [email protected]/PVB systems. Importantly, the results showed that our [email protected]/PVB systems with different release behaviors adjustable by the density and size of the pores are all effective to kill S. aureus, as the released VH concentration from the investigated systems are all well above the minimum effective concentration. This study provides a universal strategy to fabricate therapeutic drugs-loaded coatings on implants with the ability to control drug release behaviors.

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