The interaction of 6,6′-dithiodinicotinic acid with thiols and with Ehrlich ascites tumor cells☆

Add time:09/01/2019    Source:sciencedirect.com

6,6′-Dithiodinicotinic acid reacts with thiols with formation of a disulfide and 6-mercaptonicotinic acid; the reaction can be followed spectrophotometrically. Homogenates of Ehrlich ascites cells react with 6,6′-dithiodinicotinic acid to an extent approximately 4-fold that of intact cells. This suggests that the compound has difficulty in penetrating the cell. 6,6′-Dithiodinicotinic acid can cause the indirect, enzyme-mediated oxidation of glucose 6-phosphate by providing oxidized NADP. When acting on Ehrlich ascites cells, 6,6′-dithiodinicotinic acid causes a moderate stimulation of the hexose monophosphate pathway, presumably due to the reoxidation of NADPH.

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