A gas-liquid chromatographic method for the determination of butriptyline (cas 15686-37-0) in serum

Add time:09/01/2019    Source:sciencedirect.com

1.A gas-liquid chromatographic (GC) method for the analysis of butriptyline (cas 15686-37-0) in serum has been developed. Quantitation is based on the peak height ratio between butriptyline and promazine used as internal standard. A triple partition provides a “clean” extract. A detection limit of 10 ng/ml is achieved.2.The usefulness of the method has been demonstrated in bioavailability studies in dogs.

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