Biliary and urinary elimination of methadone and its metabolites in the rat
-
Add time:09/10/2019 Source:sciencedirect.com
The biliary and urinary elimination of 3H-methadone and its metabolites was quantitatively studied after various routes of administration of the drug to rats. The biliary excretion products consisted largely of the N-demethylated metabolite of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and a highly water-soluble compound which is apparently a glucuronide conjugate of a hydroxylated derivative of EDDP.Phenobarbital pretreatment of rats was found to decrease the total excretion of EDDP in the bile, possibly through enhancement of another metabolic pathway, and at the same time to decrease the duration of narcosis resulting from the administration of methadone.Pretreatment with methadone was observed to greatly enhance the rate of biliary EDDP excretion in the first 4 hr after methadone administration.
We also recommend Trading Suppliers and Manufacturers of Methadone hydrobromide (cas 19767-48-7). Pls Click Website Link as below: cas 19767-48-7 suppliers
Prev:Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure
Next:Grignard reagent-promoted 6-endo-dig cyclization: instantaneous synthesis of original dipyrido[1,2-a:3′,4′-d]imidazole) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure09/09/2019
- Research reportLocalization of methadone in the brain of young rats by computer-assisted autoradiography09/08/2019
- Methadone Hydrochloride09/07/2019
- Effect of cholinergic drugs on methadone-induced catalepsy and stereotypies in rats treated chronically with methadone09/06/2019
- Brief communicationFate of tritium derived from prenatally administered tritiated methadone in dams and neonatal rats☆09/05/2019
- Stereoselective quantification of methadone and its major oxidative metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, in human urine using high-performance liquid chromatography09/04/2019
- A randomized, double-blind, placebo-controlled safety study of high-dose dextromethorphan in methadone-maintained male inpatients09/03/2019
- Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine09/02/2019
