Grignard reagent-promoted 6-endo-dig cyclization: instantaneous synthesis of original dipyrido[1,2-a:3′,4′-d]imidazole

Add time:09/02/2019    Source:sciencedirect.com

Dipyrido[1,2-a:3′,4′-d]imidazole derivatives can be readily synthetized from various 3-alkyne-2-cyanoimidazo[1,2-a]pyridines via an efficient Grignard reagent-promoted 6-endo-dig cyclization of nitrile to alkynes. A previous optimization of the Sonogashira coupling reaction at C(3) of the 2-cyanoimidazo[1,2-a]pyridine was necessary as this coupling reaction is known to be largely influenced by the nature of the 2-substituent.

We also recommend Trading Suppliers and Manufacturers of 2-Methyl-3-cyanoimidazo(1,2-a)pyridine (cas 19768-70-8). Pls Click Website Link as below: cas 19768-70-8 suppliers

Prev:Biliary and urinary elimination of methadone and its metabolites in the rat
Next:Efficient synthesis of novel dipyridoimidazoles and pyrido[1′,2′;1,2]imidazo[4,5-d]pyridazine derivatives)