The preparation of 2-chloro-5-methyl-pyridine in airlift loop reactor

Add time:07/14/2019    Source:sciencedirect.com

A new process for the direct chlorination of 3-methyl-pyridine with special catalyst to yield 2-chloro-5-methyl-pyridine in the airlift loop reactor has been considered. The effects of reaction temperature, the molar ratio of palladium chloride to 3-methyl-pyridine, concentration of 3-methyl-pyridine, chlorine gas flowrate and the ratio of the inside diameter of the draft tube to that of the reactor on the molar yield of 2-chloro-5-methyl-pyridine were investigated and discussed, and an optimum operation condition was found. The average molar yield of 2-chloro-5-methyl-pyridine comes up to 60% under the optimum operation condition.

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